Ryan chats with Amr Awadallah, founder and CEO of GenAI platform Vectara about how retrieval-augmented generation (RAG) has advanced, why fact-checking and accurate data are essential in building AI applications, and how Vectara’s Mockingbird model seeks to minimize hallucinations.
Ryan welcomes Tomasz Tunguz of Theory Ventures back to the podcast to talk about the intersection of AI and venture capital, the implications of AI on the labor market, and the future of AI applications.
At HumanX 2025, Ryan sat down with HumanX CEO Stefan Weitz and Crunchbase CEO Jager McConnell to talk about where the money is in the AI space, where most enterprise AI strategies fall short, how companies can build business models when AI tech is evolving so quickly, and why this is AI’s microservices moment.
Two interviews for the price of one, direct from HumanX 2025! Ryan sits down with Raj Patel, AI transformation lead at Holistic AI, and then chats with Audioshake cofounder and CEO Jessica Powell.
Deepak Singh, VP of Developer Agents and Experiences at AWS, helps Ryan break down the hype around agentic AI in software development. They cover the definition and real-world functionality of AI agents, how developers can integrate them into existing workflows, and the importance of establishing guardrails to ensure trust and security in agentic AI.
Ryan speaks with Edo Liberty, Founder and CEO of Pinecone, about building vector databases, the power of embeddings, the evolution of RAG, and fine-tuning AI models.
Stack Overflow CEO Prashanth Chandrasekar sat down with Ryan at HumanX 2025 to talk about how Stack is integrating AI into its public platform, the enormous importance of a high-quality knowledge base in your AI journey, how AI tools are empowering junior developers to build better software, and much more.
Tillman Elser, AI/ML lead at Sentry, joins Ryan for a conversation about improving error monitoring with AI and ML. They talk through the challenges of analyzing stack traces, the innovative use of embeddings to improve error grouping, the trial-and-error process of developing algorithms, and where Sentry’s AI capabilities are headed next.
Some high-level takeaways, with more to come.
Lisbeth Kaufman, Head of Climate Tech at AWS, sits down with Ryan to talk about her work helping climate tech startups get off the ground and the role startups can play in addressing the climate change crisis. She highlights a few projects to get excited about, including ones focused on fusion energy and sustainable agriculture.
Ryan welcomes Zach Lloyd, founder and CEO of Warp, to the show to talk about reimagining the terminal. They also discuss why Warp was built in Rust (“it’s definitely harder”), how AI is transforming developer tools, and what Zach (formerly a principal engineer at Google) learned building Docs and Sheets.
More developers are sandwiched between caring for kids and older relatives. What does this mean for them and for the industry as a whole?
Jeremy “Jezz” Kellway, VP of Engineering for Analytics and Data & AI at EDB (Enterprise Database), joins Ryan for a conversation about Postgres and AI. They unpack how Postgres is becoming the standard database for AI applications, the importance of managing unstructured data, and the implications of data sovereignty and governance in AI.
Software security expert Tanya Janca, author of Alice and Bob Learn Secure Coding and Staff DevRel at AppSec company Semgrep, joins Ryan to talk about secure coding practices.
Olga Beregovaya, VP of AI at Smartling, joins Ryan and Ben to explore the evolution and specialization of language models in AI.
How Diffblue leverages machine learning techniques to write effective unit tests.
And how the platform engineering landscape is evolving.
Minh Nguyen, VP of Engineering at Transcend, joins Ryan for a conversation about the complexities of privacy and consent in tech, from the challenges organizations face in managing data privacy to the importance of consent management tools to the evolving landscape of privacy regulations.
Ken Stott, Field CTO of API platform Hasura, tells Ryan about the data doom loop: the concept that organizations are spending lots of money on data systems without seeing improvements in data quality or efficiency.
Sagar Batchu, CEO and cofounder of API tooling company Speakeasy, talks with Ryan about the evolving API landscape, AI integration, the role of human technologists in an increasingly automated environment, and what people building APIs right now should keep in mind.
Jaime Torrealba, a frontend developer currently at Push Security, joins Ryan to talk about 3D graphics and web development. Their conversation ranges from the evolution of technologies like WebGL and WebGPU to the importance of performance optimization for different devices to the frameworks available for creating 3D experiences. Jaime also explains the layers of abstraction in 3D development and shares some insight into what the future of 3D applications might look like.
Ryan is joined by Fynn Glover (CEO) and Ben Papillon (CTO), cofounders of Schematic, for a conversation about managing feature flags in software development. They explore theoretical and practical applications of feature flags, the issue of tech debt, and how orgs could manage entitlements and pricing models more effectively.
Ben and Ryan are joined by RJ Tuit, Head of UI Platform and Client Architect at ClickUp, formerly an engineering director at Microsoft. They talk about ClickUp’s vision for a comprehensive productivity platform, the complexities of measuring productivity and UX in software development, how to navigate the hype around AI, and more. Plus: What it was like scaling Microsoft’s cloud services to meet the unprecedented demands of a global workforce in quarantine.
John Graham-Cumming, CTO of Cloudflare, joins Ben and Ryan for a conversation about the latest trends in internet usage highlighted in Cloudflare's 2024 Year in Review report.
